Nematodes, Nervous Disease, and Neurotropic Virus Infection
نویسندگان
چکیده
منابع مشابه
The central nervous system inflammatory response to neurotropic virus infection is peroxynitrite dependent.
We have recently demonstrated that increased blood-CNS barrier permeability and CNS inflammation in a conventional mouse model of experimental allergic encephalomyelitis are dependent upon the production of peroxynitrite (ONOO(-)), a product of the free radicals NO* and superoxide (O2*(-)). To determine whether this is a reflection of the physiological contribution of ONOO(-) to an immune respo...
متن کاملCD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus.
Replication of the neurotropic mouse hepatitis virus strain JHM (JHMV) is controlled primarily by CD8(+) T-cell effectors utilizing gamma interferon (IFN-gamma) and perforin-mediated cytotoxicity. CD4(+) T cells provide an auxiliary function(s) for CD8(+) T-cell survival; however, their direct contribution to control of virus replication and pathology is unclear. To examine a direct role of CD4...
متن کاملRegulatory role of CD1d in neurotropic virus infection.
The GDVII strain of Theiler's murine encephalomyelitis virus (TMEV) causes an acute fatal polioencephalomyelitis in mice. Infection of susceptible mice with the DA strain of TMEV results in an acute polioencephalomyelitis followed by chronic immune-mediated demyelination with virus persistence in the central nervous system (CNS); DA virus infection is used as an animal model for multiple sclero...
متن کاملIs dengue virus neurotropic?
Dengue viral infection is on the rise in tropical urban and semi-urban parts of the world. WHO fact sheetN°117 updated in May 2015 estimates 390 million dengue infections per year and that 3900 million people, in 128 countries, are at risk. The WHO case definition of severe dengue includes organ impairment, but does not describe neurological manifestations as a separate entity. Earliest reports...
متن کاملBorna disease virus: molecular analysis of a neurotropic infectious agent.
Borna disease (BD) was originally described in the 1 800s as an encephalitis in horses . Though it has been confirmed to occur as a natural infection only in horses and sheep, BD has been induced experimentally in birds, rodents and primates by inoculation with brain homogenates from infected animals .' BD is characterized by behavioral abnormalities, meningeal and parenchymal inflammatory cell...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1952
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.4780.366